Born in upstate New York, Syrie Moskowitz spent most of her childhood in the deep South. She and her mother, an artist and novelist, spent extensive time traveling the country selling antiques from the back of a van. At the age of 12, Moskowitz began seriously photographing, becoming the fourth-generation photographer in her family. She also trained in theatre, modern dance, classical ballet, and piano.

At seventeen, she traveled to Eastern Europe, making a documentary in Romania, which began her career in film making. Since then, projects have led her around the globe, to create stories and record subjects in Europe, Central America, and the Middle East.

Moskowitz uses her skills and training, as well as life experiences, in directing, acting, modeling, and production design.

She has modeled for many significant artists and photographers, including Ellen Von Unwerth, George Holz, Jenny Morgan, Mark Sink, Thierry van Biesen and Mark Albeit.

Her company, Moonweasel Productions, has filmed for clients Salman Rushdie, Van Cleef and Arpel, and The Comedy Awards for Comedy Central.